About Cefprozil Second Generation Cephalosporin antibiotic, Oral antibiotic. Mechanism of Action of Cefprozil Cefprozil is a short acting 2nd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefprozil inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Indications for Cefprozil 1.Pharyngitis 2.Sinusitis 3.Pneumonia 4.Acute Bronchitis 5.Skin infection 6.Tonsillitis 7.Otitis media