About Cefixime Third Generation Cephalosporin Oral antibiotic Mechanism of Action of Cefixime Cefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria. Indications for Cefixime 1.Tonsillitis 2.Pharyngitis 3.Otitismedia 4.Bronchitis 5.Urinary tract infections 6.Gonorrhea 7.Infections caused by susceptible organisms.