About Otilonium bromide Antimuscarinic, Quaternary ammonium compound, Spasmolytic in irritable bowel and other spastic conditions. Indications for Otilonium bromide 1.Gastro intestinal tract spasm 2.Irritable bowel syndrome Typical Dosage for Otilonium bromide Oral: 20 - 40 mg 2 - 3 times daily.