About Sulindac NSAID, arylalkanoic acid derivative, Analgesic ,antiinflammatory. Mechanism of Action of Sulindac Sulindac produces its analgesics and anti-inflammatory actions by inhibiting Prostaglandin synthesis. Pharmacokinets of Sulindac Absorption: It is rapidly and completely absorbed after oral administration. Distribution: It is distributed mainly in protein bound form. Metabolism: It undergoes metabolism in the liver and produces active sulfide metabolite. Excretion: Drug and its metabolites are excreted mainly in urine.