About Sulbutiamine A synthetic derivative of thiamine, a centrally acting cholinergic agent, Nootropic,antiasthenic. Mechanism of Action of Sulbutiamine Sulbutiamine is a centrally acting cholinergic agent. This drug inhibits the enzyme Acetyl cholinesterase and prolongs the action of Acetylcholine- a stimulating hormone in the brain. This increased Acetylcholine concentrations are believed to be responsible for the improvement seen during treatment with donepezil. Sulbutiamine is a thiamine derivative. Being lipophilic it crosses the blood brain barrier and leads to increased formation of thiamine triphosphate which regulates the synaptic transmission of many neurotransmission system.