Medicine Description voriconazole-accord 200mg
Voriconazole Accord Tablets are an antifungal medicine containing voriconazole, which belongs to the triazole class of
antifungal agents. It is used to treat certain serious fungal infections.
The medicine is used to treat certain cases of invasive aspergillosis, severe Candida infections, and other fungal
infections. Treatment with voriconazole requires medical monitoring because it can interact with many medicines and
may affect liver function and vision.
Ingredients of Voriconazole Accord
The medicine contains the following active ingredient:
Voriconazole Accord Strength
The medicine is available in the following form and strength:
Uses of Voriconazole Accord
The main uses of the medicine include:
Treatment of invasive aspergillosis.
Treatment of Candida bloodstream infections in non-neutropenic patients in specific cases.
Treatment of certain serious invasive Candida infections that are resistant to fluconazole.
Treatment of certain serious infections caused by Scedosporium species.
Treatment of certain serious infections caused by Fusarium species.
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It may be used to prevent invasive fungal infections in certain high-risk patients following hematopoietic stem
cell transplantation, according to the doctor's assessment.
Voriconazole Accord Dosage
The doctor determines the appropriate dose according to the type of infection, the patient's body weight and age,
liver function, and overall health. The usual doses for adults are as follows:
| Age |
Dose |
Maximum Frequency |
| Adults weighing 40 kg or more |
Loading dose: 400 mg |
Every 12 hours during the first 24 hours |
| Adults weighing 40 kg or more |
Maintenance dose: 200 mg |
Twice daily |
| Patients weighing less than 40 kg |
Loading dose: 200 mg |
Every 12 hours during the first 24 hours |
| Patients weighing less than 40 kg |
Maintenance dose: 100 mg |
Twice daily |
How to Use Voriconazole Accord Correctly
The medicine should be used according to the doctor's instructions. The following guidelines are recommended:
Take the dose at the time prescribed by your doctor.
Take the tablets at least 1 hour before or at least 1 hour after a meal.
Swallow the tablet whole with an adequate amount of water.
Do not crush or chew the tablet unless instructed by your doctor.
Try to take the doses at the same times every day.
Do not double the dose if you miss a previous dose.
Do not stop treatment simply because your symptoms have improved without consulting your doctor.
Tell your doctor about all medicines and supplements you are taking before starting treatment.
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Your doctor may request regular liver function tests and monitoring of certain electrolytes during treatment.
Avoid driving or operating machinery if you experience visual changes or dizziness.
Contraindications of Voriconazole Accord
The medicine should not be used in patients with a known allergy to voriconazole or any of its ingredients. It is also
contraindicated with certain medicines that are highly dependent on the CYP3A4 enzyme, as increased concentrations of
these medicines may cause serious or potentially life-threatening adverse effects.
It should also not be combined at the start of treatment with phenytoin or venetoclax in certain patients, depending
on the clinical situation and treatment regimen. It is also contraindicated with strong CYP3A4 inducers. Therefore,
patients should inform their doctor about all medicines and supplements they are taking before starting treatment.
Side Effects of Voriconazole Accord
The most common possible side effects include:
Temporary visual disturbances.
Blurred vision.
Increased sensitivity to light.
Changes in or increased color perception.
Headache.
Dizziness.
Nausea.
Vomiting.
Diarrhea.
Abdominal pain.
Dry mouth.
Skin rash.
Increased liver enzyme levels.
Liver function abnormalities.
Alternatives to Voriconazole Accord in Pharmacies
The appropriate alternative may be selected according to the required dose, dosage form, and availability.
Alternatives include Voricofungal, Vorifend, Vorigrand, and Vorican. You should consult a doctor or pharmacist before
replacing the medicine to ensure that the alternative is appropriate for your condition and required dose.
Storage Conditions
The medicine should be stored under the following conditions:
Store at room temperature.
No special storage conditions are required according to the product information.
Keep the medicine in its original package to protect it from external factors.
Keep out of the reach of children.
Do not use after the expiry date stated on the package.
Dispose of unused tablets according to the pharmacist's instructions or applicable local regulations.
Frequently Asked Questions
Can Voriconazole Accord Be Taken With Food?
The medicine should not preferably be taken with food. The tablets should be taken at least 1 hour before or 1 hour
after a meal because food may reduce the absorption of voriconazole. Following this timing helps ensure optimal
effectiveness.
Is Voriconazole Accord Safe During Pregnancy?
The medicine should not be used during pregnancy unless the doctor determines that the expected benefit to the mother
outweighs the potential risks to the fetus.
Can Voriconazole Accord Be Used During Breastfeeding?
Breastfeeding is not recommended during treatment with the medicine because the transfer of voriconazole into breast
milk has not been adequately studied.
Does Voriconazole Accord Cause Sun Sensitivity?
Yes. Voriconazole may cause photosensitivity and increase the skin's sensitivity to sunlight. This may appear as
redness, rash, or skin irritation after sun exposure. It is therefore recommended to avoid direct and prolonged
exposure to sunlight, wear protective clothing, and use a high-SPF sunscreen during treatment.