Losartan tablets are an effective medication that belongs to the group of angiotensin II receptor blockers (ARBs). These coated tablets contain a potent dose of the active ingredient losartan potassium, 100 mg per tablet. Losartan is primarily used to treat essential hypertension in adults and children aged 6 years and older. Additionally, Losartan is an important treatment option for protecting the kidneys in patients with type 2 diabetes who suffer from diabetic nephropathy, characterized by elevated blood creatinine levels, and who have a history of high blood pressure. Losartan helps slow the progression of kidney damage in these patients and reduces the risk of developing advanced kidney failure.
The active ingredient in Losartan tablets
The therapeutic efficacy of Losartan tablets depends primarily on the presence of the following active ingredient in a precise and specific concentration to ensure optimal therapeutic results:
Losartan Potassium: Available in a concentration of 100 mg in each coated tablet. Losartan is a selective angiotensin II type 1 (AT1) receptor antagonist. This blocker prevents the effects of angiotensin II on blood vessels, kidneys, and adrenal glands, lowering blood pressure and protecting the kidneys.
Mechanism of Action of Losartan Tablets
Losartan works by targeting and blocking the action of angiotensin II, a powerful hormone in the body that plays a key role in regulating blood pressure and fluid and salt balance. The mechanism of action of Losartan involves the following steps:
AT1 receptor blockade: Losartan selectively binds to angiotensin II type 1 (AT1) receptors found in many tissues, including blood vessels, kidneys, heart, and adrenal glands, preventing angiotensin II from binding to these receptors.
Vasodilation: By blocking the effect of angiotensin II on blood vessels, Losartan prevents blood vessel constriction, leading to vasodilation and decreased peripheral vascular resistance, thus lowering blood pressure.
Reducing aldosterone secretion: Losartan reduces the effect of angiotensin II on the adrenal glands, reducing the secretion of aldosterone. Aldosterone is responsible for sodium and water retention in the body, which contributes to high blood pressure. Low aldosterone leads to increased sodium and water excretion, thus lowering blood pressure.
Kidney protection: In diabetic patients with diabetic nephropathy, Losartan helps reduce pressure within the glomeruli (the filtering units of the kidneys) and reduce protein leakage into the urine (proteinuria). This mechanism helps slow the progression of kidney damage and maintain kidney function for a longer period.
Indications for Use of Losartan Tablets
Losartan 100 mg tablets are used to treat the following conditions:
Essential hypertension: In adults and children aged 6 years and older, to lower blood pressure and reduce the risk of associated cardiovascular complications.
Treatment of diabetic nephropathy with elevated creatinine: In patients with type 2 diabetes who suffer from high blood pressure and proteinuria (more than 500 mg of protein in the urine per day), to slow the progression of kidney disease and reduce the risk of developing advanced kidney failure.
Losartan tablets should only be used with a prescription and under the supervision of a specialist.