Cardivo-Care tablets are a combination drug that combines two active ingredients that work synergistically and effectively to lower and control high blood pressure in adults. Each tablet contains specific doses of bisoprolol fumarate 10 mg, a beta-adrenergic blocker that primarily affects cardiovascular function. Cardivo-Care also contains hydrochlorothiazide 6.25 mg, a thiazide diuretic that increases the excretion of water and salts from the body through the kidneys. This integrated drug combination is used to treat essential hypertension in patients who have not responded adequately to treatment with either of these drugs alone, providing a more comprehensive and effective therapeutic solution for controlling blood pressure and reducing the risk of associated complications.
The active ingredient in Cardivo-Care tablets
The therapeutic efficacy of Cardivo-Care tablets depends on the presence of the following two active ingredients in precise and specific quantities to achieve the best blood pressure-lowering effect:
Bisoprolol Fumarate: Available in a concentration of 10 mg per tablet, this is a selective beta-1 adrenergic receptor blocker located primarily in the heart. Bisoprolol slows heart rate and the force of contraction of the heart muscle, reducing the amount of blood pumped by the heart per minute, thereby lowering blood pressure and reducing the workload on the heart.
Hydrochlorothiazide: Available in a concentration of 6.25 mg per tablet, this is a thiazide diuretic that works by inhibiting the reabsorption of sodium and chloride in the distal convoluted tubule of the kidneys. This results in increased excretion of water, sodium, chloride, and potassium from the body through urine, reducing blood volume and thus lowering blood pressure.
This balanced combination of a beta-blocker and a diuretic provides a more effective blood pressure-lowering effect than using either drug alone, as they target different mechanisms of blood pressure regulation in the body.
Mechanism of Action of Cardivo-Care Tablets
Cardivo-Care Tablets works by combining two distinct but complementary mechanisms to lower high blood pressure:
Mechanism of Action of Bisoprolol (Beta-blocker): Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart. Blocking these receptors results in:
Slowing down the heart rate (negative chronotropic effect).
Reducing the force of contraction of the heart muscle (negative inotropic effect).
Reducing the conduction of electrical impulses in the heart (negative dromotropic effect). All of these effects reduce the amount of blood pumped by the heart per minute (cardiac output), leading to lower blood pressure. Bisoprolol also reduces the secretion of renin from the kidneys, a hormone that contributes to high blood pressure. Mechanism of Action of Hydrochlorothiazide (Thiazide Diuretic): Hydrochlorothiazide works primarily in the kidneys by inhibiting the combined transport system of sodium and chloride in the distal convoluted tubule. This results in:
Increased urinary excretion of sodium, chloride, and water.
Reduced total blood volume.
Reduced long-term peripheral vascular resistance. The reduced blood volume reduces the workload on the heart and contributes to lowering blood pressure.
This combined, complementary action of bisoprolol and hydrochlorothiazide provides more comprehensive and effective blood pressure control than using either drug alone.
Indications for Use of Cardivo-Care Tablets
Cardivo-Care Tablets are used to treat essential hypertension (high blood pressure) in adults in the following cases:
Patients whose blood pressure has not been adequately controlled with bisoprolol or hydrochlorothiazide alone when taken at appropriate doses.
Patients who are already taking bisoprolol and hydrochlorothiazide as separate tablets and wish to simplify their treatment regimen by taking a single tablet containing both medications at the same doses should use Cardivo-Care tablets only upon prescription and under the supervision of a qualified physician.