Fluxopride tablets are an effective prokinetic drug. Each tablet contains the active ingredient mosapride citrate (5 mg). This drug improves the movement of food and fluids through the stomach and intestines, making it useful in relieving a variety of uncomfortable symptoms associated with gastrointestinal disorders. Fluxopride is primarily used to treat heartburn, gastroesophageal reflux disease (GERD), nausea, and vomiting resulting from chronic gastritis. It also plays an important role in some diagnostic procedures related to the gastrointestinal tract.
The active ingredient in Fluxopride tablets
The therapeutic efficacy of Fluxopride tablets depends primarily on the presence of the following active ingredient in a precise and specific concentration:
Mosapride citrate: Available in a 5 mg concentration per tablet, equivalent to 6.724 mg of mosapride citrate dihydrate. Mosapride is a modern and effective drug for improving upper gastrointestinal motility and has a relatively good safety profile.
Mechanism of Action of Fluxopride Tablets
Mosapride, contained in Fluxopride Tablets, selectively stimulates specific receptors in the gastrointestinal tract known as serotonin 5-HT4 (5-hydroxytryptamine 4) receptors. Activation of these receptors leads to a series of events that improve gastrointestinal motility:
Increased acetylcholine release: Activation of 5-HT4 receptors stimulates the release of the neurotransmitter acetylcholine at the nerve endings in the stomach and intestinal wall.
Improved smooth muscle motility: Acetylcholine stimulates the contraction of smooth muscles in the stomach and intestines, increasing the strength and speed of their peristaltic movements.
Accelerated gastric emptying: Improving gastric motility speeds up the emptying of food from the stomach into the duodenum, reducing the feeling of fullness and pressure in the stomach.
Improving coordination between the stomach and duodenum: Mosapride helps improve coordination between the stomach and duodenum, the first part of the small intestine, reducing acid reflux from the duodenum into the stomach.
Relieves nausea and vomiting: By improving digestive motility and reducing acid reflux, Mosapride helps relieve the symptoms of nausea and vomiting associated with slow or inflamed stomach motility.
Indications for use of Fluxopride tablets
Fluxopride tablets are primarily used to treat and relieve symptoms associated with upper gastrointestinal motility disorders, including:
Heartburn and gastroesophageal reflux disease (GERD): especially those associated with chronic gastritis, as it helps reduce acid reflux into the esophagus and relieves a burning sensation in the chest.
Nausea and vomiting: resulting from chronic gastritis or other conditions that lead to slow stomach motility.
As an adjunct to oral lavage solution after meals for barium enema examinations: It is used to improve bowel motility and facilitate radiographic examination of the large intestine after barium enema. It helps obtain clearer and more accurate images of the intestine.
The doctor may also prescribe Fluxopride for other conditions associated with upper gastrointestinal motility disorders based on their assessment of the patient's clinical condition.
How to Use Fluxopride Tablets
Flaxoproide tablets should be taken orally with a sufficient amount of water. It is preferable to take them before or after meals, as directed by the doctor. The recommended dose for adults is usually one tablet (5 mg) three times daily, before or after meals. Carefully follow the doctor's instructions regarding the dosage, timing, and duration of treatment. Do not exceed the recommended dose or stop taking the medication before the end of the prescribed period, even if you feel an improvement in your symptoms.