Diavance 5/500 mg tablets is a medication that combines glibenclamide and metformin to manage glucose levels in individuals with type 2 diabetes. Glibenclamide, a sulfonylurea, stimulates the pancreas to release more insulin in response to elevated blood glucose levels. It enhances insulin secretion from beta cells and reduces hepatic glucose production. Metformin, on the other hand, works primarily by decreasing hepatic glucose output and improving insulin sensitivity in peripheral tissues, particularly muscle and adipose tissue. Together, these mechanisms effectively lower blood sugar levels and help maintain glycemic control.
Indications and Uses of Diavance 5/500 mg tablets
- Management of type 2 diabetes mellitus in adults
- Used in combination with diet and exercise to improve glycemic control
- Recommended for patients who require more than one oral agent to achieve desired blood sugar levels
Side Effects of Diavance 5/500 mg tablets
- Nausea and vomiting
- Diarrhea
- Abdominal discomfort
- Hypoglycemia
- Weight gain
- Lactic acidosis (rare but serious)
Storage and Handling
Store at room temperature away from moisture and heat. Keep out of reach of children. Do not use past the expiration date.
Patient Advice and Precautions
Regular monitoring of blood sugar levels is essential. Patients should be advised to maintain a balanced diet and engage in physical activity. It is crucial to inform healthcare providers of any other medications being taken to avoid interactions. Patients should also be aware of symptoms of hypoglycemia and know how to manage it.
Scientific Degree: pharmacist
Country: Egypt
Dr. Rawan Mosaad El-Saeed is a clinical pharmacist and medical content reviewer holding a Bachelor of Pharmacy degree from Horus University in Egypt. She has hands-on community pharmacy experience in providing medication therapy counseling, monitoring drug-drug interactions, and ensuring patient adherence to safe usage protocols. She specializes in authoring and fact-checking pharmaceutical guides and simplifying clinical pharmacology based on the latest evidence-based guidelines and internationally accredited references, dedicated to delivering accurate, reliable, and safe healthcare information for readers.
Published Date: 19 April 2025
Source 1 :
Glibenclamide
Source 2 :
Metformin hydrochloride
you should ask your doctor before taking this medicine