Medicine Description temodal 100 mg
temodal 100 mg capsule is a medication that works as an alkylating agent, specifically through its active form, methyl-CCNU. Once administered, it undergoes spontaneous conversion to the active form in the body. This active metabolite then methylates DNA, particularly at the O6 position of guanine, leading to the formation of DNA cross-links. These cross-links prevent DNA replication and transcription, ultimately inducing cell cycle arrest and apoptosis in rapidly dividing cancer cells. The selectivity for tumor cells allows temozolomide to target and inhibit the growth of specific malignant tumors effectively, making it a critical component in the treatment of aggressive brain cancers.
Indications and Uses of temodal 100 mg capsule
- Treatment of newly diagnosed glioblastoma multiforme in conjunction with radiotherapy
- Management of recurrent glioblastoma multiforme
- Treatment of anaplastic astrocytoma after the failure of standard therapy
Side Effects of temodal 100 mg capsule
- Nausea and vomiting
- Fatigue
- Loss of appetite
- Constipation
- Headache
- Increased risk of infection due to myelosuppression
- Severe allergic reactions (rare)
Storage and Handling
Store temodal 100 mg capsules at room temperature, away from moisture and heat. Keep the medication in its original container and out of reach of children. Do not use beyond the expiration date indicated on the packaging.
Patient Advice and Precautions
It is crucial to take temodal under the supervision of a healthcare professional. Patients should be monitored regularly for blood cell counts due to the risk of myelosuppression. Do not discontinue use without consulting a physician, and inform the healthcare provider of any other medications being taken to avoid potential interactions. Patients should be advised to report any signs of infection or unusual bleeding immediately.