About Perindopril A long-acting Dicarboxylate-containing ACE inhibitor, Antihypertensive. Mechanism of Action of Perindopril It is a prodrug and converted in to active Perindoprilat- which is a long acting angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. The drug restores the reduced elastic properties of arteries and heart in hypertensive individuals. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality