About Tolmetin NSAID, arylalkanoic acid derivative, Analgesic,antiinflammatory. Mechanism of Action of Tolmetin Tolmetin is a nonsteroidal compound having anti-inflammatory, analgesics and antipyretic activities. It produces its actions by inhibiting Prostaglandin synthesis. Indications for Tolmetin 1.Rheumatoid arthritis 2.Osteoarthritis 3.Juvanile rheumatoid arthritis Typical Dosage for Tolmetin Adult:200 - 400 mg three times a day- maximum daily dose:1800mg Children above 2 years: 15- 30 mg/kg/day in 3 - 4 divided doses