Ramitac tablets are an important and widely used medication that belongs to the class of angiotensin-converting enzyme (ACE) inhibitors. This medication contains the active ingredient ramipril (2.5 mg per tablet), a pharmaceutical compound that is converted in the body to its active metabolite, which regulates blood pressure and improves heart function. Ramitac is widely used to treat high blood pressure and heart failure and plays an important role in reducing the risk of myocardial infarction, stroke, and death from cardiovascular disease in patients at risk. Ramitac is considered a valuable treatment option due to its long-term cardiovascular protection.
The active ingredient in Ramitac tablets
The therapeutic efficacy of Ramitac tablets is primarily based on the following active ingredient:
Ramipril: 2.5 mg per tablet. Ramipril is a prodrug that is converted in the liver to its active metabolite, ramiprilat, which is the effective ACE inhibitor. The 2.5 mg dose is usually the initial or maintenance dose in some cases, and may be adjusted based on the patient's response and treatment goals.
Mechanism of Action of Ramitac Tablets
Ramipril, through its active metabolite, ramiprilat, acts on the renin-angiotensin-aldosterone system, a complex hormonal system that affects blood pressure and fluid and salt balance in the body. Its primary mechanism of action is:
Angiotensin-converting enzyme (ACE) inhibition: Ramiprilat binds to and inhibits the action of angiotensin-converting enzyme (ACE). This enzyme is responsible for converting angiotensin I to angiotensin II.
Reducing Angiotensin II Levels: Angiotensin II is a powerful hormone that causes severe constriction of blood vessels, leading to high blood pressure. It also stimulates the release of aldosterone, which causes sodium and water retention, increasing blood volume.
Vasodilation: Decreased levels of angiotensin II as a result of ACE inhibition cause smooth muscle relaxation in the walls of blood vessels, causing them to dilate. This dilation reduces peripheral resistance to blood flow and thus lowers blood pressure.
Reducing aldosterone secretion: Decreased levels of angiotensin II also reduce aldosterone secretion, helping the body eliminate excess sodium and water through the kidneys. This contributes to lowering blood pressure and reducing volume overload in cases of heart failure.
Beneficial effects on the heart and blood vessels: In addition to lowering blood pressure, ramipril has direct beneficial effects on the heart and blood vessels. It helps improve left ventricular function after a myocardial infarction, reduces post-infarction cardiac remodeling, and protects blood vessels from progressive damage.
Indications for use of Ramitac tablets
Ramitac tablets are used to treat a variety of conditions related to the cardiovascular and renal systems, including:
Hypertension: Used as a single treatment or in combination with other medications to lower and control high blood pressure.
Symptomatic heart failure: Used to improve symptoms such as shortness of breath and swelling and reduce the risk of hospitalization and death in patients with heart failure following an acute myocardial infarction (MI) or one not associated with a recent MI.
Reducing the risk of myocardial infarction, stroke, or death from cardiovascular disease: In adults with evidence of underlying cardiovascular disease, such as coronary artery disease, a history of stroke, peripheral vascular disease, or diabetes with at least one other risk factor for cardiovascular disease.
Treatment of kidney disease in diabetic patients with high blood pressure (diabetic nephropathy): To help slow the progression of kidney damage and reduce the amount of protein in the urine of these patients.