Cetrotide ampoules are an innovative injectable medication that plays a crucial role in assisted reproductive technologies (ART), particularly in in vitro fertilization (IVF) procedures. Each ampoule contains 0.25 mg of the active ingredient cetrorelix, a compound belonging to the class of gonadotropin-releasing hormone (GnRH) receptor antagonists.
Cetrorelix is an essential tool in precisely controlling the complex hormonal process of ovarian stimulation. During an in vitro fertilization (IVF) cycle, the ovaries are stimulated to produce multiple eggs. However, an early surge in luteinizing hormone (LH) levels can lead to premature egg release, significantly reducing the chances of successful treatment. Cetrorelix works by binding to GnRH receptors in the pituitary gland and blocking the action of gonadotropin-releasing hormone. This, in turn, prevents the sudden release of luteinizing hormone, allowing doctors to control the timing of ovulation and ensure optimal egg maturation before fertilization.
The active ingredient in Cetrotide Ampoules
Cetrotide Ampoules contain the following active ingredient, which is the basis of its therapeutic effect in regulating hormones during fertility treatments:
Cetrorelix: 0.25 mg per ampoule. Cetrorelix is a synthetic peptide that acts as a potent gonadotropin-releasing hormone (GnRH) receptor antagonist. It binds to GnRH receptors in the pituitary gland, leading to rapid inhibition of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. Inhibiting LH secretion is crucial in assisted fertility treatments to prevent premature ovulation and ensure timely egg retrieval.
Available Strengths
Cetrotide ampoules are primarily available in one specific strength to meet the therapeutic needs of assisted reproductive treatment programs:
Cetrorelix: 0.25 mg per ampoule: This standard dosage is effective in preventing premature LH surge in most women undergoing ovarian stimulation.
In some cases, packs containing a different number of ampoules may be available to suit different treatment protocols followed by fertility specialists.
Indications for Use of Cetrotide ampoules
Cetrotide ampoules are primarily used in assisted reproductive treatment programs, specifically:
Prevention of premature LH surge: In women undergoing controlled ovarian stimulation (COS) as part of assisted fertility treatments such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Preventing premature LH surge ensures that eggs remain at optimal maturity until they are collected for fertilization.