Floxamo tablets are a combination drug that combines two powerful antibiotics: amoxicillin 500 mg and flucloxacillin 500 mg in each tablet. Both drugs belong to the penicillin family of antibiotics, a group known for their effectiveness in combating bacterial infections. Floxamo broad spectrum of antibacterial activity makes it a valuable treatment option for a variety of infections caused by different types of bacteria that affect multiple parts of the body. This integrated drug combination effectively targets and eliminates the bacteria causing the infection.
The active ingredient in Floxamo tablets
The therapeutic efficacy of Floxamo tablets depends on the presence of the following two active ingredients in specific and precise quantities:
Amoxicillin: Available in a 500 mg strength per tablet, usually as amoxicillin trihydrate, a stable form of the drug that is well absorbed orally. Amoxicillin is a broad-spectrum antibiotic effective against many Gram-positive and Gram-negative bacteria.
Flucloxacillin: Also available in a 500 mg strength per tablet, usually as flucloxacillin sodium, another stable and absorbable form. Flucloxacillin is particularly effective against certain bacteria that produce beta-lactamase, an enzyme that can inactivate some other types of penicillin. This unique combination of amoxicillin and flucloxacillin gives Flucloxacillin a broad spectrum of antibacterial activity, making it effective in treating a wide range of infections.
Mechanism of Action of Floxamo Tablets
Both the amoxicillin and flucloxacillin in Floxamo Tablets work primarily by inhibiting a vital process essential for bacterial survival and growth: the synthesis of the bacterial cell wall. The cell wall provides structural protection for bacteria, maintains their shape, and prevents their breakdown. The mechanism of action of these antibiotics includes:
Inhibiting cell wall-building enzymes: Amoxicillin and flucloxacillin bind to specific enzymes called penicillin-binding proteins (PBPs), which are essential for bacterial cell wall synthesis.
Preventing peptidoglycan formation: By binding to these enzymes, the antibiotics disrupt the final steps in the synthesis of peptidoglycan, the main component of the bacterial cell wall.
Cell wall weakness and bacterial death: As a result of inhibiting cell wall synthesis, the bacterial cell wall becomes weak, unstable, and unable to maintain cell integrity. This ultimately leads to bacterial cell lysis and death, thereby eliminating the bacterial infection.
This combination of antibiotics is characterized by its broad spectrum of activity, covering many Gram-positive bacteria (such as staphylococci and streptococci) and Gram-negative bacteria (such as some types of Escherichia coli and Haemophilus influenzae). Flucloxacillin is also effective against some strains of bacteria resistant to conventional penicillin, due to the production of the beta-lactamase enzyme.