Maxipril tablets are an effective and widely used medication that belongs to the class of angiotensin-converting enzyme (ACE) inhibitors. This medication contains the active ingredient lisinopril (20 mg per tablet), a compound that primarily acts on the hormonal system that regulates blood pressure and body fluids. Lisinopril is widely used to treat hypertension and congestive heart failure, improve survival after acute myocardial infarction in certain patients, and also treat diabetic nephropathy. Maxipril is an important treatment option due to its effectiveness, relatively good tolerability, and once-daily administration.
The active ingredient in Maxipril tablets
The therapeutic efficacy of Maxipril tablets is primarily based on the following active ingredient:
Lisinopril: 20 mg per coated tablet. Lisinopril is a potent and selective ACE inhibitor. It is an active drug in itself and does not require liver conversion to become effective, making it a suitable option for patients with liver problems.
Available Strengths of Maxipril
Maxipril tablets are usually available in a variety of strengths to meet different patient treatment needs, including:
Lisinopril: 5 mg
Lisinopril: 10 mg
Lisinopril: 20 mg
Other strengths of lisinopril may be available under different brand names or in combinations combining lisinopril with other medications, such as diuretics, to provide a variety of treatment options. The treating physician determines the appropriate strength and dosage based on a careful assessment of the patient's health condition, the severity of hypertension or heart failure, their response to treatment, and any other medications the patient may be taking.
Mechanism of Action of Maxipril Tablets
Lisinopril acts on the renin-angiotensin-aldosterone system, a hormonal system that plays a key role in regulating blood pressure and fluid and salt balance in the body. Its main mechanism of action is:
Angiotensin-converting enzyme (ACE) inhibition: Lisinopril inhibits the action of angiotensin-converting enzyme (ACE), the enzyme responsible for converting angiotensin I to angiotensin II.
Reducing angiotensin II levels: Angiotensin II is a powerful substance that causes blood vessels to constrict, raising blood pressure. It also stimulates the release of aldosterone from the adrenal gland, which leads to sodium and water retention.
Vasodilation: Decreased levels of angiotensin II cause the smooth muscles in the walls of blood vessels to relax, causing them to dilate.
Reducing aldosterone secretion: Decreased levels of angiotensin II also reduce aldosterone secretion, helping the body get rid of excess sodium and water.
Reducing the workload on the heart: By lowering blood pressure and decreasing blood volume, lisinopril reduces the workload on the heart muscle.