Epiran 75 mg tablets UAE Epiran relieves heartburn associated with indigestion and prevents heartburn associated with indigestion or eating certain foods and drinks. It treats duodenal ulcers, gastric ulcers, esophageal reflux, Zollinger-Ellison syndrome, and esophagitis. Epiran is a drug that belongs to a group of drugs called histamine 2 blockers, because it prevents histamine from reaching its receptors on the surface of stomach cells, thus reducing the production of stomach acid.